Imaging of human lymph nodes using optical coherence tomography: potential for staging cancer.
Identifieur interne : 005851 ( Main/Exploration ); précédent : 005850; suivant : 005852Imaging of human lymph nodes using optical coherence tomography: potential for staging cancer.
Auteurs : Robert A. Mclaughlin [Australie] ; Loretta Scolaro ; Peter Robbins ; Saud Hamza ; Christobel Saunders ; David D. SampsonSource :
- Cancer research [ 1538-7445 ] ; 2010.
Descripteurs français
- KwdFr :
- Carcinome canalaire du sein (anatomopathologie), Carcinome canalaire du sein (ultrastructure), Femelle, Humains, Métastase lymphatique, Noeuds lymphatiques (anatomopathologie), Noeuds lymphatiques (ultrastructure), Stade de la tumeur (), Tomographie par cohérence optique (), Tumeurs (), Tumeurs (anatomopathologie), Tumeurs (ultrastructure), Tumeurs du sein (anatomopathologie), Tumeurs du sein (ultrastructure).
- MESH :
English descriptors
- KwdEn :
- Breast Neoplasms (pathology), Breast Neoplasms (ultrastructure), Carcinoma, Ductal, Breast (pathology), Carcinoma, Ductal, Breast (ultrastructure), Female, Humans, Lymph Nodes (pathology), Lymph Nodes (ultrastructure), Lymphatic Metastasis, Neoplasm Staging (methods), Neoplasms (blood supply), Neoplasms (pathology), Neoplasms (ultrastructure), Tomography, Optical Coherence (methods).
- MESH :
- blood supply : Neoplasms.
- methods : Neoplasm Staging, Tomography, Optical Coherence.
- pathology : Breast Neoplasms, Carcinoma, Ductal, Breast, Lymph Nodes, Neoplasms.
- ultrastructure : Breast Neoplasms, Carcinoma, Ductal, Breast, Lymph Nodes, Neoplasms.
- Female, Humans, Lymphatic Metastasis.
Abstract
Histologic assessment is the gold standard technique for the identification of metastatic involvement of lymph nodes in malignant disease, but can only be performed ex vivo and often results in the unnecessary excision of healthy lymph nodes, leading to complications such as lymphedema. Optical coherence tomography (OCT) is a high-resolution, near-IR imaging modality capable of visualizing microscopic features within tissue. OCT has the potential to provide in vivo assessment of tissue involvement by cancer. In this morphologic study, we show the capability of OCT to image nodal microarchitecture through an assessment of fresh, unstained ex vivo lymph node samples. Examples include both benign human axillary lymph nodes and nodes containing metastatic breast carcinoma. Through accurate correlation with the histologic gold standard, OCT is shown to enable differentiation of lymph node tissue from surrounding adipose tissue, reveal nodal structures such as germinal centers and intranodal vessels, and show both diffuse and well circumscribed patterns of metastatic node involvement.
DOI: 10.1158/0008-5472.CAN-09-4062
PubMed: 20233873
Affiliations:
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Mclaughlin</name><affiliation wicri:level="1"><nlm:affiliation>Optical + Biomedical Engineering Laboratory, School of Electrical, Electronic, and Computer Engineering, M018, University of Western Australia, Crawley, Western Australia, Australia. robertm@ee.uwa.edu.au</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Optical + Biomedical Engineering Laboratory, School of Electrical, Electronic, and Computer Engineering, M018, University of Western Australia, Crawley, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Scolaro, Loretta" sort="Scolaro, Loretta" uniqKey="Scolaro L" first="Loretta" last="Scolaro">Loretta Scolaro</name></author><author><name sortKey="Robbins, Peter" sort="Robbins, Peter" uniqKey="Robbins P" first="Peter" last="Robbins">Peter Robbins</name></author><author><name sortKey="Hamza, Saud" sort="Hamza, Saud" uniqKey="Hamza S" first="Saud" last="Hamza">Saud Hamza</name></author><author><name sortKey="Saunders, Christobel" sort="Saunders, Christobel" uniqKey="Saunders C" first="Christobel" last="Saunders">Christobel Saunders</name></author><author><name sortKey="Sampson, David D" sort="Sampson, David D" uniqKey="Sampson D" first="David D" last="Sampson">David D. 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Mclaughlin</name><affiliation wicri:level="1"><nlm:affiliation>Optical + Biomedical Engineering Laboratory, School of Electrical, Electronic, and Computer Engineering, M018, University of Western Australia, Crawley, Western Australia, Australia. robertm@ee.uwa.edu.au</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Optical + Biomedical Engineering Laboratory, School of Electrical, Electronic, and Computer Engineering, M018, University of Western Australia, Crawley, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Scolaro, Loretta" sort="Scolaro, Loretta" uniqKey="Scolaro L" first="Loretta" last="Scolaro">Loretta Scolaro</name></author><author><name sortKey="Robbins, Peter" sort="Robbins, Peter" uniqKey="Robbins P" first="Peter" last="Robbins">Peter Robbins</name></author><author><name sortKey="Hamza, Saud" sort="Hamza, Saud" uniqKey="Hamza S" first="Saud" last="Hamza">Saud Hamza</name></author><author><name sortKey="Saunders, Christobel" sort="Saunders, Christobel" uniqKey="Saunders C" first="Christobel" last="Saunders">Christobel Saunders</name></author><author><name sortKey="Sampson, David D" sort="Sampson, David D" uniqKey="Sampson D" first="David D" last="Sampson">David D. Sampson</name></author></analytic><series><title level="j">Cancer research</title><idno type="eISSN">1538-7445</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Breast Neoplasms (pathology)</term><term>Breast Neoplasms (ultrastructure)</term><term>Carcinoma, Ductal, Breast (pathology)</term><term>Carcinoma, Ductal, Breast (ultrastructure)</term><term>Female</term><term>Humans</term><term>Lymph Nodes (pathology)</term><term>Lymph Nodes (ultrastructure)</term><term>Lymphatic Metastasis</term><term>Neoplasm Staging (methods)</term><term>Neoplasms (blood supply)</term><term>Neoplasms (pathology)</term><term>Neoplasms (ultrastructure)</term><term>Tomography, Optical Coherence (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Carcinome canalaire du sein (anatomopathologie)</term><term>Carcinome canalaire du sein (ultrastructure)</term><term>Femelle</term><term>Humains</term><term>Métastase lymphatique</term><term>Noeuds lymphatiques (anatomopathologie)</term><term>Noeuds lymphatiques (ultrastructure)</term><term>Stade de la tumeur ()</term><term>Tomographie par cohérence optique ()</term><term>Tumeurs ()</term><term>Tumeurs (anatomopathologie)</term><term>Tumeurs (ultrastructure)</term><term>Tumeurs du sein (anatomopathologie)</term><term>Tumeurs du sein (ultrastructure)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome canalaire du sein</term><term>Noeuds lymphatiques</term><term>Tumeurs</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Neoplasm Staging</term><term>Tomography, Optical Coherence</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term><term>Carcinoma, Ductal, Breast</term><term>Lymph Nodes</term><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Breast Neoplasms</term><term>Carcinoma, Ductal, Breast</term><term>Lymph Nodes</term><term>Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Lymphatic Metastasis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Carcinome canalaire du sein</term><term>Femelle</term><term>Humains</term><term>Métastase lymphatique</term><term>Noeuds lymphatiques</term><term>Stade de la tumeur</term><term>Tomographie par cohérence optique</term><term>Tumeurs</term><term>Tumeurs du sein</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Histologic assessment is the gold standard technique for the identification of metastatic involvement of lymph nodes in malignant disease, but can only be performed ex vivo and often results in the unnecessary excision of healthy lymph nodes, leading to complications such as lymphedema. Optical coherence tomography (OCT) is a high-resolution, near-IR imaging modality capable of visualizing microscopic features within tissue. OCT has the potential to provide in vivo assessment of tissue involvement by cancer. In this morphologic study, we show the capability of OCT to image nodal microarchitecture through an assessment of fresh, unstained ex vivo lymph node samples. Examples include both benign human axillary lymph nodes and nodes containing metastatic breast carcinoma. Through accurate correlation with the histologic gold standard, OCT is shown to enable differentiation of lymph node tissue from surrounding adipose tissue, reveal nodal structures such as germinal centers and intranodal vessels, and show both diffuse and well circumscribed patterns of metastatic node involvement.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Hamza, Saud" sort="Hamza, Saud" uniqKey="Hamza S" first="Saud" last="Hamza">Saud Hamza</name><name sortKey="Robbins, Peter" sort="Robbins, Peter" uniqKey="Robbins P" first="Peter" last="Robbins">Peter Robbins</name><name sortKey="Sampson, David D" sort="Sampson, David D" uniqKey="Sampson D" first="David D" last="Sampson">David D. Sampson</name><name sortKey="Saunders, Christobel" sort="Saunders, Christobel" uniqKey="Saunders C" first="Christobel" last="Saunders">Christobel Saunders</name><name sortKey="Scolaro, Loretta" sort="Scolaro, Loretta" uniqKey="Scolaro L" first="Loretta" last="Scolaro">Loretta Scolaro</name></noCountry><country name="Australie"><noRegion><name sortKey="Mclaughlin, Robert A" sort="Mclaughlin, Robert A" uniqKey="Mclaughlin R" first="Robert A" last="Mclaughlin">Robert A. Mclaughlin</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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